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. 1987 Feb;79(2):629–631. doi: 10.1172/JCI112858

Triiodothyronine enhances renal response to aldosterone in the rabbit collecting tubule.

C Barlet, A Doucet
PMCID: PMC424149  PMID: 3027130

Abstract

Since thyroid hormones and mineralocorticoids were observed to stimulate kidney Na-K-ATPase in similar sites and with similar time courses, this study was initiated to evaluate whether aldosterone is involved in the stimulation of Na-K-ATPase observed in collecting tubules 3 h after triiodothyronine (T3) administration to thyroidectomized (TX) rabbits. Results indicate that: Plasma aldosterone level decreased markedly in TX rabbits but was not restored 3 h after T3 injection; Early stimulation of Na-K-ATPase by T3 was abolished when plasma aldosterone level was suppressed by adrenalectomy or when aldosterone effects were blocked by spironolactone; Administration of aldosterone to TX rabbits mimicked the action of T3; Sensitivity of Na-K-ATPase to aldosterone markedly decreased after thyroidectomy. These results demonstrate an interaction between aldosterone and T3 in the control of Na-K-ATPase in the collecting tubule. Triiodothyronine enhances the sensitivity of Na-K-ATPase to aldosterone which, in turn, produces a stimulatory action despite the decreased plasma level observed during hypothyroidism.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barlet C., Ben Abdelkhalek M., Doucet A. Sites of thyroid hormone action on Na-K-ATPase along the rabbit nephron. Pflugers Arch. 1985 Sep;405(1):52–57. doi: 10.1007/BF00591097. [DOI] [PubMed] [Google Scholar]
  2. Barlet C., Doucet A. Kinetics of triiodothyronine action on Na-K-ATPase in single segments of rabbit nephron. Pflugers Arch. 1986 Jul;407(1):27–32. doi: 10.1007/BF00580716. [DOI] [PubMed] [Google Scholar]
  3. Doucet A., Katz A. I., Morel F. Determination of Na-K-ATPase activity in single segments of the mammalian nephron. Am J Physiol. 1979 Aug;237(2):F105–F113. doi: 10.1152/ajprenal.1979.237.2.F105. [DOI] [PubMed] [Google Scholar]
  4. EDELMAN I. S., BOGOROCH R., PORTER G. A. ON THE MECHANISM OF ACTION OF ALDOSTERONE ON SODIUM TRANSPORT: THE ROLE OF PROTEIN SYNTHESIS. Proc Natl Acad Sci U S A. 1963 Dec;50:1169–1177. doi: 10.1073/pnas.50.6.1169. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Edelman I. S., Ismail-Beigi F. Thyroid thermogenesis and active sodium transport. Recent Prog Horm Res. 1974;30(0):235–257. doi: 10.1016/b978-0-12-571130-2.50010-9. [DOI] [PubMed] [Google Scholar]
  6. El Mernissi G., Doucet A. Short-term effect of aldosterone on renal sodium transport and tubular Na-K-ATPase in the rat. Pflugers Arch. 1983 Oct;399(2):139–146. doi: 10.1007/BF00663910. [DOI] [PubMed] [Google Scholar]
  7. El Mernissi G., Doucet A. Short-term effects of aldosterone and dexamethasone on Na-K-ATPase along the rabbit nephron. Pflugers Arch. 1983 Oct;399(2):147–151. doi: 10.1007/BF00663911. [DOI] [PubMed] [Google Scholar]
  8. El Mernissi G., Doucet A. Specific activity of Na-K-ATPase after adrenalectomy and hormone replacement along the rabbit nephron. Pflugers Arch. 1984 Nov;402(3):258–263. doi: 10.1007/BF00585508. [DOI] [PubMed] [Google Scholar]
  9. Fregly M. J., Cade J. R., Waters I. W., Straw J. A., Taylor R. E., Jr Secretion of aldosterone by adrenal glands of propylthiouracil-treated rats. Endocrinology. 1965 Nov;77(5):777–784. doi: 10.1210/endo-77-5-777. [DOI] [PubMed] [Google Scholar]
  10. Geering K., Girardet M., Bron C., Kraehenbühl J. P., Rossier B. C. Hormonal regulation of (Na+,K+)-ATPase biosynthesis in the toad bladder. Effect of aldosterone and 3,5,3'-triiodo-L-thyronine. J Biol Chem. 1982 Sep 10;257(17):10338–10343. [PubMed] [Google Scholar]
  11. Geering K., Rossier B. C. Thyroid hormone-aldosterone antagonism on Na+ transport in toad bladder. Evidence for a triiodothyronine nuclear receptor. J Biol Chem. 1981 Jun 10;256(11):5504–5510. [PubMed] [Google Scholar]
  12. Haber R. S., Loeb J. N. Early enhancement of passive potassium efflux from rat liver by thyroid hormone: relation to induction of Na,K-ATPase. Endocrinology. 1984 Jul;115(1):291–297. doi: 10.1210/endo-115-1-291. [DOI] [PubMed] [Google Scholar]
  13. Montiel M., Jiménez E., Narváez J. A., Ruiz M., Morell M. Effects of two different experimental situations of hypothyroidism on serum aldosterone concentration and plasma renin in rats. Rev Esp Fisiol. 1984 Dec;40(4):431–436. [PubMed] [Google Scholar]
  14. Oppenheimer J. H., Koerner D., Schwartz H. L., Surks M. I. Specific nuclear triiodothyronine binding sites in rat liver and kidney. J Clin Endocrinol Metab. 1972 Aug;35(2):330–333. doi: 10.1210/jcem-35-2-330. [DOI] [PubMed] [Google Scholar]
  15. Oppenheimer J. H. Thyroid hormone action at the cellular level. Science. 1979 Mar 9;203(4384):971–979. doi: 10.1126/science.218285. [DOI] [PubMed] [Google Scholar]
  16. PORTER G. A., BOGOROCH R., EDELMAN I. S. ON THE MECHANISM OF ACTION OF ALDOSTERONE ON SODIUM TRANSPORT: THE ROLE OF RNA SYNTHESIS. Proc Natl Acad Sci U S A. 1964 Dec;52:1326–1333. doi: 10.1073/pnas.52.6.1326. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Philipson K. D., Edelman I. S. Characteristics of thyroid-stimulated Na+-K+-ATPase of rat heart. Am J Physiol. 1977 May;232(5):C202–C206. doi: 10.1152/ajpcell.1977.232.5.C202. [DOI] [PubMed] [Google Scholar]
  18. Philipson K. D., Edelman I. S. Thyroid hormone control of Na+-K+-ATPase and K+-dependent phosphatase in rat heart. Am J Physiol. 1977 May;232(5):C196–C201. doi: 10.1152/ajpcell.1977.232.5.C196. [DOI] [PubMed] [Google Scholar]
  19. Philipson K. D., Edelman I. S. Thyroid hormone control of Na+-K+-ATPase and K+-dependent phosphatase in rat heart. Am J Physiol. 1977 May;232(5):C196–C201. doi: 10.1152/ajpcell.1977.232.5.C196. [DOI] [PubMed] [Google Scholar]
  20. Rossier B. C., Gäggeler H. P., Brunner D. B., Keller I., Rossier M. Thyroid hormone-aldosterone interaction on Na+ transport in toad bladder. Am J Physiol. 1979 Mar;236(3):C125–C131. doi: 10.1152/ajpcell.1979.236.3.C125. [DOI] [PubMed] [Google Scholar]
  21. TAYLOR R. E., Jr, FREGLY M. J. RENAL RESPONSE OF PROPYLTHIOURACIL-TREATED RATS TO INJECTED MINERALOCORTICOIDS. Endocrinology. 1964 Jul;75:33–41. doi: 10.1210/endo-75-1-33. [DOI] [PubMed] [Google Scholar]
  22. Truscello A., Gäggeler H. P., Rossier B. C. Thyroid hormone antagonizes an aldosterone-induced protein: a candidate mediator for the late mineralocorticoid response. J Membr Biol. 1986;89(2):173–183. doi: 10.1007/BF01869713. [DOI] [PubMed] [Google Scholar]

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