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DDB1 binding motif found in DCAFs. (A), A DDB1-WD40 box (DWD) domain is present in some WD40-repeat-containing proteins [19] and mediates the binding of these DCAFs to DDB1. The 16-aa motif, estimated to occur in 79 genes in humans, is based on the biochemical/biophysical properties of the aa. (B), HBx sequences from three HBV subtypes show a similar DWD motif. Reproduced with permission from Reference [78]. Copyright 2008, Research Signpost.
