Laparoscopic robotic-assisted gastrointestinal surgery: the Geneva experience

Abstract

The continuing development of robotic surgery supports its use in laparoscopic gastrointestinal surgery. Our study retrospectively reviewed the surgical outcome and patient’s satisfaction of gastrointestinal laparoscopic robotic procedures. From January 2003 to September 2007, 94 patients (27 women, 67 men) with a mean age of 53 years (range 19–84 years) underwent laparoscopic surgery with a da Vinci robotic system. There were 40 colorectal cases (43%), 31 anti-reflux surgery cases (33%) and 14 obesity surgery cases (15%); the remaining cases consisted of gastric and gallbladder surgery, intra-abdominal tumour excisions, and hepatic cyst resections. The majority of the cases (88, 94%) were performed for benign disease. The mean operative time was 153 min (range 60–330 min). One patient needed a blood transfusion. The mean body mass index was 25 (range 16–47). No death occurred. Five cases (5.3%) were converted to conventional laparoscopic surgery (n = 3) or to laparotomy (n = 2). Morbidity consisted of one Nissen redo surgery to loosen a tight anti-reflux valve 6 days after robotic surgery, a robotic left ureter repair and pelvic haemorrhage following proctectomy requiring re-operation to control haemostasis and to remove pelvic haematoma. Mean follow-up time was 11 months (range 15 days to 34 months). One case of incisional trocar hernia needed re-operation. Overall patient’s satisfaction was high: few scars were cheloïd, while functional surgical outcome was rated high by most of the patients. Our preliminary experience was encouraging, with minimal morbidity and very high acceptance by patients.

Introduction

In 1987, the first laparoscopic cholecystectomy was performed by P. Mouret [1]. Ten years later, Himpens et al. performed the first robotic cholecystectomy using a prototype system with remote control and a three-dimensional viewing through the use of specially developed glasses [2].

More sophisticated robotic systems were later developed which provided – or improved upon – a stable camera platform, three-dimensional imaging, excellent ergonomics, instruments with a wide-range degree of freedom and modulation of motion amplitude with tremor filtering. The current da Vinci robotic system (Intuitive Surgical, Sunnyvale, CA) is the most highly used system worldwide. The first da Vinci system was installed in Geneva in 2003, and to the best of our knowledge, our team has had the most experience among Swiss clinicians in gastrointestinal cases using this system.

The aim of the study reported here was to determine surgical feasibility, evaluate functional outcome and assess patients’ satisfaction using this system.

Material and methods

To date, 94 consecutive patients have been treated by our team. From January 2003 to December 2006, the three-arm da Vinci system was used (73 cases), and from January 2007 to September 2007, our team used the four-arm da Vinci system (21 cases). During the entire study period, 409 robotic procedures were performed at our institution, consisting of 300 urologic cases (73%), 94 gastrointestinal cases (23%) and 15 gynecologic cases (4%). Each patient’s data were prospectively collected using a robotic logbook; a clinical information sheet for each individual was filled up by the surgeon and anesthesiologist and later stored in our computerized database system. A retrospective analysis was then performed to retrieve data. The follow-up was done during a patient's visit to the attending physician and/or telephone interview. The patient's evaluation was obtaining using a visual analog score (1–10). Approval by our local Ethics Committee was obtained prior to carrying out this study.

Results

They were 27 men (29%) and 67 women (71%) in our patient cohort, with a mean age of 53 years (range 19–84 years). Overall, mean hospital stay was 7 days (range 2–24 days), and mean body mass index (BMI) was 25 (range 16–47). A blood transfusion was needed in one case (1%). Benign cases accounted for 88 patients (94%). Only six patients (6%) had malignant diseases: five colorectal adenocarcinomas and one intra-abdominal teratoma. The surgical procedures consisted of 40 colorectal cases (43%), 31 anti-reflux cases (33%), 14 morbid obesity cases (15%) and nine miscellaneous cases (10%).

Colorectal procedures consisted of sigmoidectomy (n = 20), sigmoidectomy and rectopexy (n = 8), right colectomy (n = 3), rectopexy (n = 3), low anterior resection (n = 2), caecectomy (n = 1), anterior resection (n = 1), abdomino-perineal resection (n = 1) and resection of recto-vaginal endometriosis nodule (n = 1). Diagnoses prior to the surgical procedure were: diverticular disease (n = 20, 50%), rectal prolapse (n = 11, 27.5%), adenocarcinoma (n = 6, 15%), benign multiple polyp or endoscopically non-resectable polyp (n = 2, 5%) and recto-vaginal endometriosis (n = 1, 2.5%). The mean age of patients undergoing colorectal procedures was 60 years (range 32–84 years). The mean hospital stay was 9 days (range 3–24), and the mean BMI was 22 (range 19–40). Mean operative time was 162 min (range 60–330 min). Two patients were re-operated (one for a left ureter injury in which a robotic suture was performed, another for pelvic bleeding by conventional laparoscopy). There were three conversions to laparoscopy (two cases for difficult dissection, one for a robotic technical problem) and two conversions to laparotomy (one robotic technical problem, and one difficult dissection). Finally, one patient developed a trocar incisional hernia.

The second most frequent procedure was Nissen fundoplication for gastro-esophageal reflux disease. The mean age of patients undergoing this procedure was 49 years (range 19–68 years). The mean hospital stay was 6 days (range 4–13 days), while the mean BMI was 27.3 (range 19–36). The mean operative time was 166 min (range 60–270 min). Associated cholecystectomy was performed in four cases. Two patients required a Nissen redo procedure, and there was one conversion to laparotomy during a Nissen redo because of an esophageal tear.

Gastric banding was the third most common surgical procedure in our series (14 cases). The mean age of patients undergoing this procedure was 41 years (range 20–58 years). The mean hospital stay was 4 days (range 3–7 days), and mean BMI was 41 (range 34–46). The mean operative time was 141 min (range 90–240 min). One patient had had a previous laparoscopic gastric banding. There was one conversion to laparotomy.

Among the miscellaneous procedures, there were four intra-abdominal tumor resections (three benign cysts and one teratoma), two cholecystectomies, two partial gastric resections and one case of hepatic cyst resection.

A patient's satisfaction was evaluated using a visual analog score system: the mean value of functional outcome of the surgical procedure was 8 (range 3–10), and of satisfaction with regard to the entire procedure was 7 (range 2–10). Five patients developed cheloid scars (5%). Mean follow-up time for all patients was 11 months (range 15 days to 34 months). Six patients were lost to follow-up (6%).

Discussion

Several studies have reported surgical results using the da Vinci robotic system in which this technique has been shown to be applicable and safe [3–9]. No morbidity related to the system has yet been observed. Overall, the reported mortality rate has ranged between 0 and 1.8%, while the rate of complication has been less than 10%; conversion to conventional laparoscopy and/or laparotomy was less than 5%. Almost all studies reported a longer operative time using the robotic system as compared to conventional laparoscopy. Increased overall costs due to longer operative time and the use of more expensive instruments was reported for cases of Nissen fundoplication and colectomy [10–15].

Our team has not experienced the death of a patient during the robotic procedure, and we have observed a morbidity of 3.1%. Conversion to laparoscopy/laparotomy was 5.3%. At the beginning of our learning experience, operative time was long, and although it has diminished with time and experience, it is still longer than conventional laparoscopy. To date, no proven patient-specific advantage of robotic surgery over laparoscopic techniques has been demonstrated. The robotic system allows the surgeon to perform more sophisticated procedures, whereas classical gastrointestinal procedures can be performed safely. The development of mini robots and augmented reality techniques will boost robotic surgery in the future [9, 16]. We have found that colon and rectum resections, anti-reflux surgery, and obesity surgery were safe and efficacious for the patients.

Several authors have reported good results with colorectal robotic surgery [17–25]. Our experience in terms of operative time, conversion rate, mortality, complications rate and length of stay are similar to those reported in the literature (Table 1). It is our impression that the use of the da Vinci system is from a technical point of view particularly useful for proctectomy with total mesorectum excision (TME) in cases of rectal cancer [25], as lymph node harvesting, nerve sparing and anatomical TME is enhanced by the three-dimensional vision of the pelvis. As reported by others, we prefer to do a hybrid procedure (conventional laparoscopic inferior mesenteric high vessel ligature and splenic flexure take down) and robotic proctectomy with TME [6]. This approach prevents a prolonged operative time and the unnecessary displacing of the robot. Right colectomy for cancer with primary vessels ligation can be performed robotically with great ease; at the end of the procedure, the anastomosis is performed outside the abdomen. Sigmoidectomy for benign disease can also be performed easily as no high vascular ligature is necessary and the splenic flexure is left in place. The operative time for a right colectomy is shorter than that for a left colectomy [24].

Table 1.

Literature survey of robotic colon and rectum surgery

Author	Year	Number of cases	Mean operative time, minutes (range)	Conversion (%)	Mortality (%)	Complications (%)	Mean length of hospital stay, days (range)
Delaney et al. [18]	2003	6	217 (170–270)	16.6	0	0	3 (2–5)
Giulanotti et al. [6]	2003	16	202 (150–360)	0	0	0	NA
Anvari et al. [19]	2004	10	155 ± 13.6	0	0	10	NA
D’Annibale et al. [20]	2004	53	240 ± 61	3.7	0	7.5	10 ± 4
Hanly and Talamini [28]	2004	35	177	14.2	NA	NA	NA
Hubens et al. [29]	2004	8	124 (87–144)	0	0	37.5	NA
Woeste et al. [21]	2005	6	236 ± 5.8	16.6	0	16.6	NA
Bodner et al. [7]	2005	14	310	0	0	0	NA
Braumann et al. [22]	2005	5	201 (80–300)	40	0	0	13.6 (9–14)
DeNoto et al. [23]	2006	11	195 (145–345)	9	0	0	3.4 (3–4)
Rawlings et al. [24]	2006	30	RC 177 (103–306) LC 225 (147–283)	6.6	0	20	RC 5.2 (2–27) LC 6 (3–30)
Pigazzi et al. [25]	2006	6	280 (200–330)	0	0	16.6	4.5 (3–11)
Current series	2007	40	162 (60–330)	12.5	0	5	9 (3–24)

NA, Not available

Given the limited space for dissection and the need to mobilize the great gastric curvature, robotic Nissen fundoplication and other anti-reflux techniques have been often performed [3–4, 6, 11–13, 26–32]. The surgical outcome of our series is in line with other reports as shown in Table 2. Randomized controlled trials have demonstrated that conventional Nissen fundoplication give similar results to the robotic approach, but it is less expensive and less time consuming [11–13, 32]. Cost analysis should be performed in each country as health systems are differ significantly.

Table 2.

Literature survey of robotic Nissen fundoplication

Author	Year	Number of cases	Mean operative time, minutes (range)	Conversion (%)	Mortality (%)	Complications (%)	Mean length of stay, hours (range)
Cadière et al. [3]	2001	36	82 (54–125)	5.5	0	0	2 (1–4)
Chitwood et al. [4]	2001	14	107 ± 3.2	0	0	0	NA
Giulanotti et al. [6]	2003	49	110 (40–300)	2	0	5	4
Benincà et al. [23]	2003	13	97.1 (77–126)	0	0	7.6	3.2 (2–7)
Hanly and Talamini [28]	2004	57	192	22.8	0	NA	NA
Hubens et al. [29]	2004	9	100 (83–139)	0	0	NA	NA
Anvari et al. [30]	2005	13	73 (45–90)	NA	0	NA	NA
D’annibale et al. [20]	2006	21	140 (60–240)	0	0	9.5	7.6 (4–11)
El Nakadi et al. [11]	2006	9	137 ± 12	11.1	0	11.1	4.4 ± 0.2
Morino et al. [12]	2006	25	131.3 (90–162)	8	0	0	3 (2–6)
Müller-Stich et al. [13]	2007	20	88 (60–150)	0	0	0	2.9 ± 0.8
Heemskerk et al. [15]	2007	11	220	0	0	9	4
Current series	2007	31	166 (60–270)	3.3	0	3.3	6 (4–13)

NA, Not available

It has recently been suggested that the use of the da Vinci robotic system is valuable for obesity surgery, specifically in cases of gastric banding [3, 7, 29, 33–35] and gastric bypass surgery [36, 37]. Our current experience in obesity surgery is associated with gastric banding devices. The surgical outcome is shown in Table 3. The totally robotic Roux-en-Y gastric bypass is feasible and safe, but this technique is still being evaluated and compared to conventional laparoscopy, although it seems promising in terms of surgical outcome and BMI reduction [36, 37].

Table 3.

Literature survey of robotic gastric banding

Author	Year	Number of cases	Mean operative time, minutes (range)	Conversion (%)	Mortality (%)	Complications (%)	Mean length of stay, days (range)
Cadière et al. [3]	2001	10	60 (55–90)	0	0	0	2 (2–3)
Mühleman et al. [33]	2003	6	137 (11–175)	0	0	0	NA
Jacobsen [34]	2003	32	105 (60–150)	0	0	3.1	1 (0.2–6)
Nguyen [35]	2004	2	NA	NA	0	NA	NA
Hubens et al. [29]	2004	7	NA	NA	0	NA	NA
Bodner et al. [7]	2005	10	167	0	0	0	NA
Current series	2007	14	141 (90–240)	12.5	0	5	4 (3–7)

NA, Not available

Da Vinci robotic use is being developed in foregut surgery, i.e. Heller myotomy and gastric cancer resections [38–40]. Future developments will include technologies of information systems, virtual reality, and micro-robotics [41].

In conclusion, our preliminary experience with 94 cases is very encouraging. The da Vinci system is safe. Surgical outcome is good and patients’ satisfaction is rated high. Future developments in gastrointestinal robotic surgery should include cost analysis studies and evaluations of quality of life outcomes.