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. 1995 Mar 14;92(6):2413–2417. doi: 10.1073/pnas.92.6.2413

Alloantigen priming induces a state of unresponsiveness in human umbilical cord blood T cells.

G Risdon 1, J Gaddy 1, M Horie 1, H E Broxmeyer 1
PMCID: PMC42494  PMID: 7892281

Abstract

Induction of alloreactivity in human adult and umbilical cord blood T cells was evaluated in mixed leukocyte culture by exposure to an allogeneic lymphoblastoid line that expresses known costimulatory molecules. Initial exposure to alloantigen-presenting cells (allo-APC) induced strong proliferative responses in both adult and cord blood T cells. However, in contrast to adult T cells, cord blood T cells exhibited little proliferation after restimulation with donor APC. Primed cord blood T cells could respond to interleukin 2 (IL-2), but unresponsiveness to alloantigen was not overcome by addition of exogenous IL-2. Unresponsiveness was long-lasting and appeared to be maintained by a combination of induction of anergy and activity of CD8+ suppressor cells. This information may contribute to use of human cord blood as an allogeneic source of transplantable stem cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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