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. 1995 Feb 28;92(5):1342–1346. doi: 10.1073/pnas.92.5.1342

p53-mediated cellular response to DNA damage in cells with replicative hepatitis B virus.

A Puisieux 1, J Ji 1, C Guillot 1, Y Legros 1, T Soussi 1, K Isselbacher 1, M Ozturk 1
PMCID: PMC42515  PMID: 7877979

Abstract

Wild-type p53 acts as a tumor suppressor gene by protecting cells from deleterious effects of genotoxic agents through the induction of a G1/S arrest or apoptosis as a response to DNA damage. Transforming proteins of several oncogenic DNA viruses inactivate tumor suppressor activity of p53 by blocking this cellular response. To test whether hepatitis B virus displays a similar effect, we studied the p53-mediated cellular response to DNA damage in 2215 hepatoma cells with replicative hepatitis B virus. We demonstrate that hepatitis B virus replication does not interfere with known cellular functions of p53 protein.

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