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. 2014 Sep 8;5(19):9444–9459. doi: 10.18632/oncotarget.2452

Figure 8. The model of miR-524-5p in MAPK/ERK signaling.

Figure 8

(A) In wild-type BRAF cells, the activity of MAPK/ERK signaling and the expression of miR-524-5p reached a steady state, resulting in the balance of cell proliferation, migration, and survival. In contrast, (B) MAPK/ERK signaling is highly activated in mutated BRAF cells, but the expression of miR-524-5p is significantly decreased, resulting in the enhancement of cell proliferation, migration, and survival. Moreover, (C) the overexpression of miR-524-5p in mutated BRAF cells significantly suppresses MAPK/ERK activity and reduces cell proliferation, migration, and survival.