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. 2014 Nov 10;143(4):670–678. doi: 10.1111/imm.12350

Figure 3.

Figure 3

Interferon-α (IFN-α) down-regulates the expression of A20 and up-regulates the expression of HLA-DR, CD86 and CCR7 in myeloid dendritic cells (mDCs). The mDCs isolated from healthy subjects (n = 10) and treatment-naive patients (n = 10) were cultured in medium alone, or in medium containing polyI:C, IFN-α, or IFN-α/polyI:C. The expression of A20, HLA-DR, CD86 and CCR7 was then detected by flow cytometry. The percentage (mean ± SD) and the mean fluorescence intensity (MFI) of mDCs expressing A20 (a), HLA-DR (b), CD86 (c) or CCR7 (d) are shown. *P < 0·05; **P < 0·01; ***P < 0·001.