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Myeloid dendritic cells (mDCs) show increased production of interleukin-12 (IL-12) and decreased production of IL-10 upon treatment with interferon-α (IFN-α). The mDCs isolated from healthy subjects (n = 10) and treatment-naive patients (n = 10) were cultured in medium alone or in medium containing polyI:C, IFN-α, or IFN-α/polyI:C. The levels of IL-12 (a) or IL-10 (b) secreted into the culture supernatants were measured by ELISA. Data represent the mean ± SD. *P < 0·05; ***P < 0·001.
