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. 1984 Dec;74(6):1961–1965. doi: 10.1172/JCI111616

Activation of the complement system in patients with porphyrias after irradiation in vivo.

H W Lim, M B Poh-Fitzpatrick, I Gigli
PMCID: PMC425382  PMID: 6392339

Abstract

Irradiation of the forearms of two patients with erythropoietic protoporphyria and one patient with porphyria cutanea tarda resulted in an in vivo activation of the complement system, as assessed by diminution of the hemolytic titers of the third component of complement by 23-57%, and of the fifth component of complement (C5) by 19-47%. Such treatment also generated chemotactic activity for human polymorphonuclear cells; the chemotactic activity was stable at 56 degrees C and antigenically related to human C5. On Sephadex G-75 chromatography the chemotactic activity eluted with an apparent molecular weight of 15,000. These in vivo results extend our previous in vitro observation of photoactivation of complement in sera from patients with erythropoietic protoporphyria and porphyria cutanea tarda, and suggest that the complement system may participate in the pathogenesis of cutaneous phototoxicity in these patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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