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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Virology. 2014 Aug 20;0:57–62. doi: 10.1016/j.virol.2014.07.052

Fig. 1. The Py-miRNA targets Smad2 and results in reduced apoptosis.

Fig. 1

A. Sequence comparison between Py-miRNA and murine Smad2 3′UTR. B. Western blot of Smad2 expression between uninfected, WT-infected, and miRNA-deficient mutant Py-infected baby mouse kidney cells. Smad2 expression was lowered with WT Py virus, but not with miRNA-deficient mutant Py. C. Caspase 3 activity assay of WT-infected and miRNA-deficient mutant Py-infected IMCD cells treated with etoposide. WT but not mutant virus inhibits etoposide induced apoptosis (** p-value < 0.01).