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. 1985 Jun;75(6):2091–2093. doi: 10.1172/JCI111929

Prevention of autoantibody formation and prolonged survival in New Zealand black/New Zealand white F1 mice fed dehydroisoandrosterone.

J A Lucas, S A Ahmed, M L Casey, P C MacDonald
PMCID: PMC425571  PMID: 3159756

Abstract

Dehydroisoandrosterone, administered orally to New Zealand Black/New Zealand White F1 hybrid mice, prevented the formation of antibodies to double-stranded DNA and prolonged survival in this murine model of lupus erythematosus.

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Selected References

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  1. Coleman D. L., Leiter E. H., Applezweig N. Therapeutic effects of dehydroepiandrosterone metabolites in diabetes mutant mice (C57BL/KsJ-db/db). Endocrinology. 1984 Jul;115(1):239–243. doi: 10.1210/endo-115-1-239. [DOI] [PubMed] [Google Scholar]
  2. Coleman D. L., Leiter E. H., Schwizer R. W. Therapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice. Diabetes. 1982 Sep;31(9):830–833. doi: 10.2337/diab.31.9.830. [DOI] [PubMed] [Google Scholar]
  3. Coleman D. L., Schwizer R. W., Leiter E. H. Effect of genetic background on the therapeutic effects of dehydroepiandrosterone (DHEA) in diabetes-obesity mutants and in aged normal mice. Diabetes. 1984 Jan;33(1):26–32. doi: 10.2337/diab.33.1.26. [DOI] [PubMed] [Google Scholar]
  4. Dubois E. L., Horowitz R. E., Demopoulos H. B., Teplitz R. NZB/NZW mice as a model of systemic lupus erythematosus. JAMA. 1966 Jan 24;195(4):285–289. [PubMed] [Google Scholar]
  5. Fernandes G., Yunis E. J., Good R. A. Influence of diet on survival of mice. Proc Natl Acad Sci U S A. 1976 Apr;73(4):1279–1283. doi: 10.1073/pnas.73.4.1279. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Fernandes G., Yunis E. J., Jose D. G., Good R. A. Dietary influence on antinuclear antibodies and cell-mediated immunity in NZB mice. Int Arch Allergy Appl Immunol. 1973;44(6):770–782. doi: 10.1159/000230981. [DOI] [PubMed] [Google Scholar]
  7. Fernandes G., Yunis E. J., Smith J., Good R. A. Dietary influence on breeding behavior, hemolytic anemia, and longevity in NZB mice. Proc Soc Exp Biol Med. 1972 Apr;139(4):1189–1196. doi: 10.3181/00379727-139-36327. [DOI] [PubMed] [Google Scholar]
  8. Gilliam J. N., Hurd E. R., Ziff M. Subepidermal deposition of immunoglobulin in NZB/NZW F hybrid mice. J Immunol. 1975 Jan;114(1 Pt 1):133–137. [PubMed] [Google Scholar]
  9. HOLMES M. C., BURNET F. M. THE NATURAL HISTORY OF AUTOIMMUNE DISEASE IN NZB MICE. A COMPARISON WITH THE PATTERN OF HUMAN AUTOIMMUNE MANIFESTATIONS. Ann Intern Med. 1963 Sep;59:265–276. doi: 10.7326/0003-4819-59-3-265. [DOI] [PubMed] [Google Scholar]
  10. Hurd E. R., Johnston J. M., Okita J. R., MacDonald P. C., Ziff M., Gilliam J. W. Prevention of glomerulonephritis and prolonged survival in New Zealand Black/New Zealand White F1 hybrid mice fed an essential fatty acid-deficient diet. J Clin Invest. 1981 Feb;67(2):476–485. doi: 10.1172/JCI110056. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Roubinian J. R., Papoian R., Talal N. Androgenic hormones modulate autoantibody responses and improve survival in murine lupus. J Clin Invest. 1977 Jun;59(6):1066–1070. doi: 10.1172/JCI108729. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Roubinian J. R., Talal N., Greenspan J. S., Goodman J. R., Siiteri P. K. Delayed androgen treatment prolongs survival in murine lupus. J Clin Invest. 1979 May;63(5):902–911. doi: 10.1172/JCI109390. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Roubinian J. R., Talal N., Greenspan J. S., Goodman J. R., Siiteri P. K. Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in NZB/NZW F1 mice. J Exp Med. 1978 Jun 1;147(6):1568–1583. doi: 10.1084/jem.147.6.1568. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Roubinian J., Talal N., Siiteri P. K., Sadakian J. A. Sex hormone modulation of autoimmunity in NZB/NZW mice. Arthritis Rheum. 1979 Nov;22(11):1162–1169. doi: 10.1002/art.1780221102. [DOI] [PubMed] [Google Scholar]
  15. Safai-Kutti S., Fernandes G., Wang Y., Safai B., Good R. A., Day N. K. Reduction of circulating immune complexes by calorie restriction in (NZB x NZW) F1 mice. Clin Immunol Immunopathol. 1980 Mar;15(3):293–300. doi: 10.1016/0090-1229(80)90041-0. [DOI] [PubMed] [Google Scholar]
  16. Schwartz A. G., Hard G. C., Pashko L. L., Abou-Gharbia M., Swern D. Dehydroepiandrosterone: an anti-obesity and anti-carcinogenic agent. Nutr Cancer. 1981;3(1):46–53. doi: 10.1080/01635588109513700. [DOI] [PubMed] [Google Scholar]
  17. Schwartz A. G. Inhibition of spontaneous breast cancer formation in female C3H(Avy/a) mice by long-term treatment with dehydroepiandrosterone. Cancer Res. 1979 Mar;39(3):1129–1132. [PubMed] [Google Scholar]
  18. Schwartz A. G., Tannen R. H. Inhibition of 7,12-dimethylbenz[a]anthracene- and urethan-induced lung tumor formation in A/J mice by long-term treatment with dehydroepiandrosterone. Carcinogenesis. 1981;2(12):1335–1337. doi: 10.1093/carcin/2.12.1335. [DOI] [PubMed] [Google Scholar]
  19. Siiteri P. K., MacDonald P. C. Placental estrogen biosynthesis during human pregnancy. J Clin Endocrinol Metab. 1966 Jul;26(7):751–761. doi: 10.1210/jcem-26-7-751. [DOI] [PubMed] [Google Scholar]
  20. VANDEWIELE R. L., MACDONALD P. C., GURPIDE E., LIEBERMAN S. STUDIES ON THE SECRETION AND INTERCONVERSION OF THE ANDROGENS. Recent Prog Horm Res. 1963;19:275–310. [PubMed] [Google Scholar]
  21. Weindruch R. H., Kristie J. A., Cheney K. E., Walford R. L. Influence of controlled dietary restriction on immunologic function and aging. Fed Proc. 1979 May;38(6):2007–2016. [PubMed] [Google Scholar]
  22. Yen T. T., Allan J. A., Pearson D. V., Acton J. M., Greenberg M. M. Prevention of obesity in Avy/a mice by dehydroepiandrosterone. Lipids. 1977 May;12(5):409–413. doi: 10.1007/BF02533624. [DOI] [PubMed] [Google Scholar]
  23. Zurier R. B., Damjanov I., Sayadoff D. M., Rothfield N. F. Prostaglandin E1 treatment of NZB/NZW F1 hybrid mice. II. Prevention of glomerulonephritis. Arthritis Rheum. 1977 Nov-Dec;20(8):1449–1456. doi: 10.1002/art.1780200802. [DOI] [PubMed] [Google Scholar]
  24. Zurier R. B., Sayadoff D. M., Torrey A. B., Rothfield N. F. Prostaglandin E treatment of NZB/NZW mice. Arthritis Rheum. 1977 Mar;20(2):723–728. doi: 10.1002/art.1780200213. [DOI] [PubMed] [Google Scholar]

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