Figure 1.

Positive examples of elderly patients with grade 2 gliomas. (A): Presurgical magnetic resonance imaging (MRI) of a 70-year-old man who presented with seizures. The patient underwent surgical resection, and definite diagnosis consisted of 1p/19q codeleted, IDH1 mutated grade 2 oligodendroglioma. No complementary treatment was administered. (B): At last follow-up, 5 years after surgery, the patient is doing well (Karnofsky performance score [KPS] = 90%) with an MRI showing an excellent persistent response. (C): Diagnostic MRI showing an infiltrative left temporal lesion in a 73-year-old patient. A biopsy was performed, and the diagnosis of non-1p/19q codeleted, IDH1 mutated grade 2 astrocytoma was retained. The patient was followed closely without any further treatment. (D): Five years later, radiological signs of progression were observed, and treatment with temozolomide was started. (E): At last follow-up, 4 years after chemotherapy, the patient (who is now 82 years old) is clinically (KPS = 80%) and radiologically stable.