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. 1995 Feb 28;92(5):1664–1668. doi: 10.1073/pnas.92.5.1664

A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens.

T K McDaniel 1, K G Jarvis 1, M S Donnenberg 1, J B Kaper 1
PMCID: PMC42580  PMID: 7878036

Abstract

Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli O157:H7 are intestinal pathogens that profoundly damage the microvilli and subapical cytoskeleton of epithelial cells. Here we report finding in EPEC a 35-kbp locus containing several regions implicated in formation of these lesions. DNA probes throughout this locus hybridize to E. coli O157:H7 and other pathogens of three genera that cause similar lesions but do not hybridize to avirulent members of the same species. The EPEC locus and a different virulence locus of uropathogenic E. coli insert into the E. coli chromosome at the identical site and share highly similar sequences near the point of insertion.

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Selected References

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