Figure 9. Plasma concentration-time profile and tissue distribution profile of HS-133 following oral (PO) administration or intravenous (IV) administration to mice.

(A) Pharmacokinetic profile of HS-133 after PO administration or IV injection at 5 mg/kg in ICR mice (n=5). The pharmacokinetic parameters of HS-133 are shown in Table 1. (B) Variety of tissues concentration of HS-133 following PO administration (10 mg/kg) to SkBr3 xenograft mice.