Fig. 4.

Appetitive and aversive spatial reference memory tasks. (a) GRM2^−/− mice acquired the appetitive spatial reference memory Y-maze task as well as the WT controls. Data shown are mean percent correct responses (±SEM) for each block of 10 trials. (b) GRM2^−/− mice also learned the aversive, swimming spatial reference memory Y-maze task at the same rate as WT mice. Data shown are mean percent correct responses (±SEM) for each block of 5 trials. (c) In the probe test on day 7 of the aversive, swimming Y-maze task, GRM2^−/− and WT mice spent an equal proportion of time searching in the arm that had previously held the platform (TRA). Thirty three percent time in an arm reflects chance performance (broken line). (d) GRM3^−/− mice displayed similar acquisition of the appetitive spatial reference memory Y-maze task as the WT controls. Data shown are mean percent correct responses (±SEM) for each block of 10 trials. (e) GRM3^−/− mice also learned the aversive, swimming spatial reference memory Y-maze task at the same rate as WT mice. Data shown are mean percent correct responses (±SEM) for each block of 5 trials. (f) In the probe test on day 7 of the aversive, swimming Y-maze task, GRM3^−/− and WT mice spent an equal proportion of time searching in the arm that had previously held the platform (TRA). Thirty three percent time in an arm reflects chance performance (broken line). Acquisition data were analysed using a two way, repeated measures ANOVA. Time spent in the target arm during the probe test at the end of training for the two groups were compared using a t-test. Order of testing and the rooms in which the tests were performed were fully counterbalanced. n = 15 WT; n = 14 GRM2^−/−; n = 15 WT; n = 15 GRM3^−/− mice.