Table 1.
Patient characteristics, laboratory parameters, and cytogenetic findings in patients younger than 50 years and patients 50 years or older
| Factor | Age category |
P | |
|---|---|---|---|
| Younger than 50 y, no. (%) | At least 50 y, no. (%) | ||
| Male | 1023/1689 (61) | 5014/8860 (57) | .002 |
| Performance status 2+ | 562/1582 (36) | 3603/8328 (43) | < .001 |
| ISS | |||
| Stage I | 492/1267 (39) | 1790/6776 (26) | < .001 |
| Stage II | 438/1267 (35) | 2675/6776 (39) | < .001 |
| Stage III | 337/1267 (27) | 2311/6776 (34) | < .001 |
| Durie-Salmon stages I or II | 612/1530 (40) | 3669/7731 (47) | < .001 |
| Stage I | 108/1333 (8) | 494/6168 (8) | .910 |
| Stage II | 307/1333 (23) | 1612/6168 (26) | .019 |
| Stage III | 918/1530 (60) | 4062/7731 (53) | < .001 |
| Subtype A | 1422/1676 (85) | 7198/8800 (82) | .003 |
| IgG | 924/1538 (60) | 4853/8091 (60) | .943 |
| IgA | 318/1538 (21) | 2009/8091 (25) | < .001 |
| IgD | 43/1538 (3) | 251/8091 (3) | .522 |
| Light chain only | 197/1538 (13) | 824/8091 (10) | .002 |
| Measurable M-protein | 1091/1340 (81) | 6695/7754 (86) | < .001 |
| More than 3 lytic lesions | 617/1292 (48) | 3457/7423 (47) | .431 |
| No bone lesions | 293/1387 (21) | 1756/8000 (22) | .492 |
| β2M ≥3.5 mg/dL (≥0.2975 μM) | 613/1377 (45) | 4141/7061 (59) | < .001 |
| Albumin <3.5 g/dL | 458/1396 (33) | 3276/7912 (41) | < .001 |
| HGB <10 g/dL | 596/1614 (37) | 3465/8539 (41) | .006 |
| Creatinine ≥2 mg/dL (≥76.8 μM) | 240/1594 (15) | 1484/8573 (17) | .028 |
| Platelets <(130 × 103)μL | 152/1420 (11) | 984/8168 (12) | .148 |
| Calcium ≥10 mg/dL (≥2.5 mM) | 481/1445 (33) | 2652/7870 (34) | .762 |
| CRP 0.8 mg/dL or more | 169/695 (24) | 1099/3740 (29) | .007 |
| Bone marrow plasma cells 33% or more | 892/1544 (58) | 4877/8250 (59) | .325 |
| LDH above normal | 158/600 (26) | 888/3365 (26) | .977 |
Where conventional units of measure are given in column 1, SI units follow in parentheses.