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. Author manuscript; available in PMC: 2014 Dec 9.
Published in final edited form as: Oncogene. 2012 Apr 23;32(9):1135–1143. doi: 10.1038/onc.2012.135

Figure 1. Inhibition of Rac and p38 increases VAMP2 positive vesicle mobility in merlin-null schwannoma.

Figure 1

Human schwannoma cells transfected with VAMP-2-GFP expressing plasmid display a large number of discrete intracellular vesicles (A). The cumulative vesicle motility is depicted by combining all images of the time lapse from live cells that were imaged at 3 second intervals for a total of 3 minutes (B). Frequency histograms show the mobile fraction of VAMP2-GFP vesicles per 3 second interval. C) NHSC, mean ±SEM: 4.2 ± 0.1. D) schwannoma, mean ±SEM: 2.0 ± 0.1. E) schwannoma + NSC23766, mean ±SEM: 6.0 ± 0.1. F) schwannoma + SB203580, mean ±SEM: 5.8 ± 0.1.