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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Gut. 2014 May 8;64(1):168–179. doi: 10.1136/gutjnl-2013-306043

Figure 7. Long-term lithium carbonate therapy primarily for the concomitant psychiatric disorders inhibits GSK3β activity in the liver and improves liver histopathology in patients with chronic hepatitis C.

Figure 7

Representative micrographs of liver biopsy specimens from chronic hepatitis C patients treated without (A, B, C) or with (D, E, F) lithium chloride. The liver biopsy specimens were subjected to hematoxylin and eosin staining and immunoperoxidase staining for pGSK3β and Nrf2. As a negative control, the primary antibody was replaced by preimmune IgG and no specific staining was noted.