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. 1972 Feb;69(2):353–357. doi: 10.1073/pnas.69.2.353

A Ribosome Dissociation Factor from Rabbit Reticulocytes

Nicolette H Lubsen 1, Bernard D Davis 1
PMCID: PMC426456  PMID: 4551141

Abstract

A ribosome dissociation factor has been detected in an extract of ribosomal particles from rabbit reticulocytes. This factor dissociates free ribosomes from reticulocytes and also from Escherichia coli; it does not dissociate ribosomes complexed with peptidyl-tRNA and mRNA. The reaction appears to be stoichiometric rather than catalytic; it reaches completion in one minute at 37°C, but is very slow at 0°C, and it is antagonized and reversed by Mg++. Reticulocyte dissociation factor thus closely resembles that from E. coli. However, the activity has been found primarily associated with the native large subunits rather than the small subunits in lysates.

Keywords: fluoride, E. coli ribosomes, initiation factors

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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