Abstract
Lambdoid phages form clear plaques and show reduced ability to establish immunity in strains of Escherichia coli that lack adenylate cyclase or catabolite activator protein. The absence of the activator protein or cyclic AMP reduces the frequency of lysogenization, but does not prevent steady-state repressor synthesis of a lysogen. Lambda phage mutants able to form turbid plaques on strains that lack catabolite activator protein or adenylate cyclase have been isolated and analyzed.
Keywords: cyclic AMP
Full text
PDF




Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brachet P., Thomas R. Mapping and functional analysis of y and CII mutants. Mutat Res. 1969 Mar-Apr;7(2):257–260. doi: 10.1016/0027-5107(69)90041-4. [DOI] [PubMed] [Google Scholar]
- Calef E., Neubauer Z. Active and inactive states of the CI gene in some lambda defective phages. Cold Spring Harb Symp Quant Biol. 1968;33:765–767. doi: 10.1101/sqb.1968.033.01.087. [DOI] [PubMed] [Google Scholar]
- Echols H., Green L. Establishment and maintenance of repression by bacteriophage lambda: the role of the cI, cII, and c3 proteins. Proc Natl Acad Sci U S A. 1971 Sep;68(9):2190–2194. doi: 10.1073/pnas.68.9.2190. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Eisen H. A., Fuerst C. R., Siminovitch L., Thomas R., Lambert L., Pereira da Silva L., Jacob F. Genetics and physiology of defective lysogeny in K12 (lambda): studies of early mutants. Virology. 1966 Oct;30(2):224–241. doi: 10.1016/0042-6822(66)90098-5. [DOI] [PubMed] [Google Scholar]
- Eisen H., Brachet P., Pereira da Silva L., Jacob F. Regulation of repressor expression in lambda. Proc Natl Acad Sci U S A. 1970 Jul;66(3):855–862. doi: 10.1073/pnas.66.3.855. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Eisen H., Pereira da Silva L., Jacob F. Sur la régulation précoce du bactériophage lambda. C R Acad Sci Hebd Seances Acad Sci D. 1968 Mar 11;266(11):1176–1178. [PubMed] [Google Scholar]
- Emmer M., deCrombrugghe B., Pastan I., Perlman R. Cyclic AMP receptor protein of E. coli: its role in the synthesis of inducible enzymes. Proc Natl Acad Sci U S A. 1970 Jun;66(2):480–487. doi: 10.1073/pnas.66.2.480. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Eron L., Arditti R., Zubay G., Connaway S., Beckwith J. R. An adenosine 3':5'-cyclic monophosphate-binding protein that acts on the transcription process. Proc Natl Acad Sci U S A. 1971 Jan;68(1):215–218. doi: 10.1073/pnas.68.1.215. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gottesman S., Beckwith J. R. Directed transposition of the arabinose operon: a technique for the isolation of specialized transducing bacteriophages for any Escherichia coli gene. J Mol Biol. 1969 Aug 28;44(1):117–127. doi: 10.1016/0022-2836(69)90408-2. [DOI] [PubMed] [Google Scholar]
- Hong J. S., Smith G. R., Ames B. N. Adenosine 3':5'-cyclic monophosphate concentration in the bacterial host regulates the viral decision between lysogeny and lysis. Proc Natl Acad Sci U S A. 1971 Sep;68(9):2258–2262. doi: 10.1073/pnas.68.9.2258. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KAISER A. D. Mutations in a temperate bacteriophage affecting its ability to lysogenize Escherichia coli. Virology. 1957 Feb;3(1):42–61. doi: 10.1016/0042-6822(57)90022-3. [DOI] [PubMed] [Google Scholar]
- Perlman R. L., Pastan I. Pleiotropic deficiency of carbohydrate utilization in an adenyl cyclase deficient mutant of Escherichia coli. Biochem Biophys Res Commun. 1969 Sep 24;37(1):151–157. doi: 10.1016/0006-291x(69)90893-6. [DOI] [PubMed] [Google Scholar]
- Reichardt L., Kaiser A. D. Control of lambda repressor synthesis. Proc Natl Acad Sci U S A. 1971 Sep;68(9):2185–2189. doi: 10.1073/pnas.68.9.2185. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Silverstone A. E., Arditti R. R., Magasanik B. Catabolite-insensitive revertants of lac promoter mutants. Proc Natl Acad Sci U S A. 1970 Jul;66(3):773–779. doi: 10.1073/pnas.66.3.773. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Silverstone A. E., Magasanik B., Reznikoff W. S., Miller J. H., Beckwith J. R. Catabolite sensitive site of the lac operon. Nature. 1969 Mar 15;221(5185):1012–1014. doi: 10.1038/2211012b0. [DOI] [PubMed] [Google Scholar]
- Zubay G., Schwartz D., Beckwith J. Mechanism of activation of catabolite-sensitive genes: a positive control system. Proc Natl Acad Sci U S A. 1970 May;66(1):104–110. doi: 10.1073/pnas.66.1.104. [DOI] [PMC free article] [PubMed] [Google Scholar]