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. 1972 Feb;69(2):383–387. doi: 10.1073/pnas.69.2.383

Epstein-Barr Virus: Transformation, Cytopathic Changes, and Viral Antigens in Squirrel Monkey and Marmoset Leukocytes

George Miller *,†, Thomas Shope †, Hermann Lisco ‡, Daphne Stitt †, Muriel Lipman *
PMCID: PMC426463  PMID: 4333982

Abstract

Blood leukocytes of two species of new world primates, other than human, transform following exposure to Epstein-Barr virus. The transformed simian cells produce Epstein-Barr virus antigens and infectious (transforming) virus. The simian lymphoblastoid cells form multinucleate giant cells that appear to be selective sites for the production of Epstein-Barr virus. Multinucleate cells reveal intranuclear inclusions; in both species, a large proportion of giant cells contain Epstein-Barr virus antigen detectable by immunofluorescence.

Keywords: human placental fibroblasts, complement fixation, immunofluorescence, electron microscopy, herpesvirus

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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