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. 1995 Feb 14;92(4):1108–1112. doi: 10.1073/pnas.92.4.1108

A sauvagine/corticotropin-releasing factor receptor expressed in heart and skeletal muscle.

T Kishimoto 1, R V Pearse 2nd 1, C R Lin 1, M G Rosenfeld 1
PMCID: PMC42647  PMID: 7755719

Abstract

Corticotropin-releasing factor (CRF) mediates many critical aspects of the physiological response to stress. These effects are elicited by binding to specific high-affinity receptors, which are coupled to guanine nucleotide stimulatory factor (Gs)-response pathways. Recently, a gene encoding a receptor for CRF, expressed in pituitary and the central nervous system (PC-CRF receptor), was isolated and characterized. Here we report the identification and characterization of a second, distinct CRF receptor that is expressed primarily in heart and skeletal muscle and exhibits a specific ligand preference and antagonist sensitivity compared with the PC-CRF receptor. We refer to this second receptor as the heart/muscle (HM)-CRF receptor.

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Selected References

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