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. 1972 Mar;69(3):539–543. doi: 10.1073/pnas.69.3.539

Stimulation by Dopamine of Adenylate Cyclase in Retinal Homogenates and of Adenosine-3′:5′-Cyclic Monophosphate Formation in Intact Retina

Joan Heller Brown 1,2, Maynard H Makman 1,2
PMCID: PMC426502  PMID: 4401122

Abstract

A catecholamine-sensitive adenylate cyclase system is present in homogenates of both calf and rat retinas. Dopamine is a more potent activator of the bovine enzyme than is norepinephrine or epinephrine. Cyclic AMP concentrations in intact bovine retina are increased by dopamine, as well as by other catecholamines, and by depolarizing agents. Studies with adrenergic blocking agents suggest that the stimulation of retinal adenylate cyclase by catecholamines cannot be clearly defined in terms of the characteristics of alpha or beta adrenergic receptors. Bovine retina also contains a protein kinase that is stimulated 20-fold by cyclic AMP. It is proposed that dopamine is the major activator of a retinal adenylate cyclase, and that this activation is related to its role as a neurotransmitter.

Keywords: adrenergic receptors, epinephrine, norepinephrine, protein kinase, ouabain

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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