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. 1972 Mar;69(3):594–598. doi: 10.1073/pnas.69.3.594

A Factor That Can be Used to Regulate an In Vitro Primary Immune Response

James Watson 1, Marilyn Thoman 1
PMCID: PMC426514  PMID: 4551977

Abstract

A factor has been isolated that supports the stimulation of an immune response against heterologous erythrocyte antigens in mouse spleen cells cultured in a medium that contains deficient serum. The factor is secreted by certain spleen cells that are obtained in permanent culture after leukemia virus infection. The factor permits antigen-sensitive cells derived from bone marrow to mature to antibody-forming cells. This factor can be used in controlling the initiation of a primary immune response in vitro.

Keywords: mice, Rauscher leukemia virus, spleen cells, plaque-forming cells

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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