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. 1972 Mar;69(3):608–612. doi: 10.1073/pnas.69.3.608

Restriction of the Mobility of Lymphocyte Immunoglobulin Receptors by Concanavalin A

Ichiro Yahara 1, Gerald M Edelman 1
PMCID: PMC426517  PMID: 4551979

Abstract

The induction by anti-immunoglobulin of patch and cap formation on mouse lymphocytes was inhibited by the addition of concanavalin A. This effect was reversed by α-methyl-D-mannoside, a competitive inhibitor of the binding of concanavalin A. Concanavalin A prevented both patch and cap formation, in contrast to the metabolic inhibitor NaN3, which prevented only cap formation. This suggests that binding of concanavalin A induces changes on or in the lymphocyte membrane that inhibit free diffusion of immunoglobulin receptors.

Keywords: lymphocyte receptors, lectin, NaN3, cell membranes, fluorescence microscopy

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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