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. 2015 Jan 1;5(1):12–22. doi: 10.7150/thno.8799

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Patients stratification and combination of kinase inhibitors. (A) Graph illustrates the accumulation of high level of pH3T6, pH3S10 and pH3Y41 in 42 GBM. (B) Correlation between the accumulation of high level of pH3T6, pH3S10 and pH3Y41 and the overall survival of GBM patients. Each circle represents a GBM. (C) Effect of combinantion of kinases inhibitors on TMZ+Irrad-induced apoptosis. PCTC#19 presenting a high level of pH3 were treated with adequate kinase inhibitors. The effects of these treatments were estimated by monitoring the pH3 level by ELISA. Cell death is next estimated by using a Trypan Blue Stain 0.4%, and the Countess® Automated Cell Counter (Life Technology, France) after the TMZ+Irrad treatment (Temozomide+Irradiation treatment). m: median.