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. 1972 Apr;69(4):882–884. doi: 10.1073/pnas.69.4.882

Complete Amino-Acid Sequence of Calf-Thymus Histone III

Robert J Delange 1,2, John A Hooper 1,2, Emil L Smith 1,2
PMCID: PMC426586  PMID: 4502939

Abstract

Calf-thymus histone III is a single polypeptide chain of 135 residues (combined molecular weight of 15,324) with alanine at both the amino and carboxyl ends. The NH2-terminal region (Residues 1-53) of histone III is strongly basic (net charge of +18) and contains lysines-14 and -23, which are ε-N-acetylated in a fraction of the molecules, as well as lysines-9 and -27, which are partially ε-N-methylated. The COOH-terminal region (Residues 54-135) is only slightly basic (net charge of +4), contains most of the hydrophobic residues, and has a 29-residue sequence that lacks a basic residue. The two cysteines are in the nonbasic region at positions 96 and 110. A few sequence similarities of calf-thymus histone III with other histones have been noted.

Keywords: acetyllysine, methyllysine, acetylation, methylation

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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