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. 1972 May;69(5):1114–1118. doi: 10.1073/pnas.69.5.1114

T4 Transfer RNAs: Codon Recognition and Translational Properties

Neal H Scherberg 1,2, Samuel B Weiss 1,2
PMCID: PMC426642  PMID: 4504324

Abstract

T4 phage transfer RNAs recognize the previously assigned codons for a given amino acid; however, they tend to prefer code words that are less well recognized by their host. The phage transfer RNAs are more effective in polypeptide synthesis with T4 rather than Escherichia coli messenger RNAs.

Keywords: aminoacyl-tRNAs, Escherichia coli B

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Crick F. H. Codon--anticodon pairing: the wobble hypothesis. J Mol Biol. 1966 Aug;19(2):548–555. doi: 10.1016/s0022-2836(66)80022-0. [DOI] [PubMed] [Google Scholar]
  2. Daniel V., Sarid S., Littauer U. Z. Amino acid acceptor activity of bacteriophage T4 transfer RNA. FEBS Lett. 1968 Nov;2(1):39–41. doi: 10.1016/0014-5793(68)80095-x. [DOI] [PubMed] [Google Scholar]
  3. Daniel V., Sarid S., Littauer U. Z. Bacteriophage induced transfer RNA in Escherichia coli. New transfer RNA molecules are synthesized on the bacteriophage genome. Science. 1970 Mar 27;167(3926):1682–1688. doi: 10.1126/science.167.3926.1682. [DOI] [PubMed] [Google Scholar]
  4. Gesteland R. F., Salser W., Bolle A. In vitro synthesis of T4 lysozyme by suppression of amber mutations. Proc Natl Acad Sci U S A. 1967 Nov;58(5):2036–2042. doi: 10.1073/pnas.58.5.2036. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gold L. M., Schweiger M. Synthesis of phage-specific alpha- and beta-glucosyl transferases directed by T-even DNA in vitro. Proc Natl Acad Sci U S A. 1969 Mar;62(3):892–898. doi: 10.1073/pnas.62.3.892. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hayatsu H., Wataya Y., Kai K., Iida S. Reaction of sodium bisulfite with uracil, cytosine, and their derivatives. Biochemistry. 1970 Jul 7;9(14):2858–2865. doi: 10.1021/bi00816a016. [DOI] [PubMed] [Google Scholar]
  7. Hsu W. T., Weiss S. B. Selective translation of T4 template RNA by ribosomes from T4-infected Escherichia coli. Proc Natl Acad Sci U S A. 1969 Sep;64(1):345–351. doi: 10.1073/pnas.64.1.345. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kan J., Nirenberg M. W., Sueooka N. Coding specificity of Escherichia coli leucine transfer ribonucleic acids and effect of bacteriophage T2 infection. J Mol Biol. 1970 Sep 14;52(2):179–193. doi: 10.1016/0022-2836(70)90024-0. [DOI] [PubMed] [Google Scholar]
  9. Kelmers A. D., Novelli G. D., Stulberg M. P. Separation of transfer ribonucleic acids by reverse phase chromatography. J Biol Chem. 1965 Oct;240(10):3979–3983. [PubMed] [Google Scholar]
  10. Klem E. B., Hsu W. T., Weiss S. B. The selective inhibition of protein initiation by T4 phage-induced factors. Proc Natl Acad Sci U S A. 1970 Oct;67(2):696–701. doi: 10.1073/pnas.67.2.696. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Leder P., Singer M. F., Brimacombe R. L. Synthesis of trinucleoside diphosphates with polynucleotide phosphorylase. Biochemistry. 1965 Aug;4(8):1561–1567. doi: 10.1021/bi00884a015. [DOI] [PubMed] [Google Scholar]
  12. Scherberg N. H., Weiss S. B. Detection of bacteriophage T4- and T5-coded transfer RNAs. Proc Natl Acad Sci U S A. 1970 Nov;67(3):1164–1171. doi: 10.1073/pnas.67.3.1164. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Tillack T. W., Smith D. W. The effect of bacteriophage T2 infection of the synthesis of transfer RNA in Escherichia coli. Virology. 1968 Oct;36(2):212–222. doi: 10.1016/0042-6822(68)90138-4. [DOI] [PubMed] [Google Scholar]
  14. Weiss S. B., Hsu W. T., Foft J. W., Scherberg N. H. Transfer RNA coded by the T4 bacteriophage genome. Proc Natl Acad Sci U S A. 1968 Sep;61(1):114–121. doi: 10.1073/pnas.61.1.114. [DOI] [PMC free article] [PubMed] [Google Scholar]

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