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. 1972 Jun;69(6):1371–1374. doi: 10.1073/pnas.69.6.1371

Cooperation of Mitochondrial and Nuclear Genes Specifying the Mitochondrial Genetic Apparatus in Neurospora crassa

Zoltan Barath 1,*, Hans Küntzel 1
PMCID: PMC426704  PMID: 4260903

Abstract

Enzymes involved in the expression of the mitochondrial genome in Neurospora crassa are induced by chloramphenicol and ethidium bromide, which block transcription and translation of mitochondrial DNA. It is concluded that most, if not all, proteins of the mitochondrial genetic apparatus are coded by nuclear genes, synthesized on cytoplasmic ribosomes, and controlled by a repressor-like mitochondrial gene product. A model explaining the coordination of nuclear and mitochondrial division cycles by repressor control is discussed.

Keywords: chloramphenicol, ethidium bromide, repressor control, model

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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