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. 1972 Jun;69(6):1416–1420. doi: 10.1073/pnas.69.6.1416

Variable Decay of Memory and Its Recovery in Cycloheximide-Treated Mice

Larry R Squire 1, Samuel H Barondes 1
PMCID: PMC426715  PMID: 4504352

Abstract

Mice were trained in an automated visual-discrimination task. When injected with cycloheximide before training, mice showed: (a) some impairment of memory within minutes after the beginning of training, (b) gradual development of total amnesia in less than 3 hr or in more than 6 hr after training, depending on the extent of training, and (c) spontaneous recovery of memory within 3 days after training. The results are consistent with the operation of three processes of memory storage: (i) a short-term process that is independent of protein synthesis, (ii) a long-term that is dependent on protein synthesis, and (iii) a slow-developing memory storage that becomes apparent during the days after training.

Keywords: amnesia, protein synthesis, discrimination task

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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