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. 1972 Jun;69(6):1421–1424. doi: 10.1073/pnas.69.6.1421

Inhibition of Influenza Virus Replication by α-Amanitin: Mode of Action

B W J Mahy 1, N D Hastie 1, Sylvia J Armstrong 1
PMCID: PMC426716  PMID: 4504353

Abstract

The replication of influenza virus in chick embryo fibroblast cells is inhibited by α-amanitin added during the first 2 hr of infection at concentrations similar to those required to inhibit cellular DNA-dependent RNA polymerase form II in vivo. Of two periods of increased RNA synthesis observed in cells infected with influenza virus, only the first, occurring from 0 to 2 hr after infection, is sensitive to α-amanitin. During this early period, there is a stimulation of the activity of DNA-dependent RNA polymerase II of nuclei isolated from infected cells. The data suggest that DNA transcription mediated by polymerase II is essential for influenza virus replication.

Keywords: chick embryo fibroblast, nucleus, polymerase II, parainfluenza virus

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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