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. 1972 Jun;69(6):1490–1493. doi: 10.1073/pnas.69.6.1490

Third Party Mixed-Leukocyte Culture Test: A Potential New Method of Histocompatibility Testing

B H Park 1, R A Good 1
PMCID: PMC426733  PMID: 4113869

Abstract

The disparity index is an expression of histocompatibility difference between two siblings with identical human leukocyte antigen (HL-A) type who are nonreactive in mixed leukocyte culture (MLC) test. This index is derived from a third-party MLC test. The disparity index was found to be correlated with the severity of graft-versus-host reaction in bone marrow transplantation between HL-A-identical siblings. The disparity index may prove to be a useful means of predicting the severity of graft-versus-host reaction and the outcome of bone marrow graft when HL-A- and MLC-matched sibling donors are studied. The third-party MLC test is offered as a new method of histocompatibility testing. It may provide a useful model for the study of immunogenetics relative to so-called weaker histocompatibility determinants in man and experimental animals.

Keywords: disparity index, graft-versus-host reaction

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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