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. 1972 Jun;69(6):1540–1544. doi: 10.1073/pnas.69.6.1540

Myeloma Proteins as Tumor-Specific Transplantation Antigens

Richard G Lynch 1,*, Ralph J Graff 1,†, Stitaya Sirisinha 1,‡, Ernest S Simms 1, Herman N Eisen 1
PMCID: PMC426744  PMID: 4113870

Abstract

BALB/c mice immunized with myeloma proteins 315 or 460 made antibodies to the individually specific (“idiotypic”) determinants of these proteins and suppressed growth of the corresponding transplanted tumor cells (MOPC-315 or MOPC-460). Stable, variant MOPC-315 tumors that produce only the light chain of protein 315 grew in several of the mice immunized with this protein, probably because the anti-idiotypic immune response selects against those myeloma cells that form the intact myeloma protein.

Keywords: BALB; c mice; plasmacytomas; tumor variants; idiotypes; anti-2,4-dinitrophenyl

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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