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. 1972 Jul;69(7):1693–1696. doi: 10.1073/pnas.69.7.1693

Is Prolactin Mitogenic for Mammary Epithelium?

Takami Oka 1, Yale J Topper 1
PMCID: PMC426780  PMID: 4505647

Abstract

Prolactin administration to mature virgin mice leads to prolilferation of epithelium of the mammary gland. In organ culture, prolactin is not mitogenic, but insulin and insulin-free serum are. These observations are reconciled by the finding that insensitive epithelium is sensitized to insulin and/or serum by prolactin treatment in vivo. Thus, it appears that prolactin acts indirectly as a mitogen by rendering the cells susceptible to the aforementioned mitogens.

Keywords: mouse, insulin, serum, organ culture, DNA, pregnancy

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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