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. 1972 Jul;69(7):1858–1862. doi: 10.1073/pnas.69.7.1858

Induction of Immunological Tolerance to Soluble Histocompatibility-2 Antigens of Mice

Lloyd W Law 1,2, Ettore Appella 1,2, Samuel Strober 1,2, Peter W Wright 1,2, Thomas Fischetti 1,2
PMCID: PMC426819  PMID: 4114856

Abstract

Immunological tolerance to a soluble, partially purified fraction of histocompatibility (H)-2a antigen was induced in B10.D2 strain mice. The fraction used was obtained after chromatography on a Sephadex G-150 column. Tolerance of humoral-antibody formation (cytotoxins and hemagglutinins) was observed in mice injected with soluble antigen since birth, but cell-mediated immunity, as measured by skin graft survival, remained intact. Tolerance was shown to be specific for H-2a antigens, since treated mice produced a regular humoral-antibody response to H-2b antigens. These findings, along with previous observations of the immunogenic and enhancing properties of our partially purified fraction, suggest that the solubilized antigen contains all the major determinants of H-2a antigens expressed on lymphoid-cell surfaces.

Keywords: cytotoxins, hemagglutinins, skin grafting

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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