Abstract
The decarboxylation of DOPA by erythrocyte hemolysates differs from DOPA decarboxylation catalyzed by aromatic aminoacid decarboxylases that contain vitamin B6 in several significant respects. The ability of erythrocyte hemolysates to decarboxylate DOPA is associated with interaction between DOPA and methemoglobin; the ferriheme protein is reduced and DOPA is decarboxylated, probably after oxidation to a quinone intermediate. An analogous reaction takes place between DOPA and other ferriheme proteins, such as metmyoglobin and cytochrome c. This phenomenon may be of significance in relation to the side effects observed in patients with Parkinson's disease who are treated with very large doses of DOPA.
Keywords: human, dopamine, Parkinson's disease, hemoglobin, myoglobin
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Selected References
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- AWAPARA J., SANDMAN R. P., HANLY C. Activation of DOPA decarboxylase by pyridoxal phosphate. Arch Biochem Biophys. 1962 Sep;98:520–525. doi: 10.1016/0003-9861(62)90220-5. [DOI] [PubMed] [Google Scholar]
- BUZARD J. A., NYTCH P. D. The effect of norepinephrine on the 5-hydroxytryptophan decarboxylase activity of rat kidney. J Biol Chem. 1959 Apr;234(4):884–888. [PubMed] [Google Scholar]
- Bryson G., Bischoff F. Dopamine transport in human blood. Clin Chem. 1970 Apr;16(4):312–317. [PubMed] [Google Scholar]
- Christenson J. G., Dairman W., Udenfriend S. Preparation and properties of a homogeneous aromatic L-amino acid decarboxylase from hog kidney. Arch Biochem Biophys. 1970 Nov;141(1):356–367. doi: 10.1016/0003-9861(70)90144-x. [DOI] [PubMed] [Google Scholar]
- FELLMAN J. H. Purification and properties of adrenal L-DOPA decarboxylase. Enzymologia. 1959 Jul 15;20:366–376. [PubMed] [Google Scholar]
- GREEN S., MAZUR A., SHORR E. Mechanism of the catalytic oxidation of adrenaline by ferritin. J Biol Chem. 1956 May;220(1):237–255. [PubMed] [Google Scholar]
- Porter C. C. Aromatic amino acid decarboxylase inhibitors. Fed Proc. 1971 May-Jun;30(3):871–876. [PubMed] [Google Scholar]
- Tate S. S., Sweet R., McDowell F. H., Meister A. Decrease of the 3,4-dihydroxyphenylalanine (DOPA) decarboxylase activities in human erythrocytes and mouse tissues after administration of DOPA. Proc Natl Acad Sci U S A. 1971 Sep;68(9):2121–2123. doi: 10.1073/pnas.68.9.2121. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yamabe H., Lovenberg W. Decarboxylation of 3,4-dihydroxyphenylalanine by oxyhemoglobin. Biochem Biophys Res Commun. 1972 May 26;47(4):733–739. doi: 10.1016/0006-291x(72)90553-0. [DOI] [PubMed] [Google Scholar]