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| KHM-3S cells | pEGFR | pAKT | pERK | pMET |
|---|---|---|---|---|
| Control | 1 | 1 | 1 | 1 |
| Erlotinib alone | 0.008 | 0.609 | 0.18 | 1.098 |
| Erlotinib + HGF | 0.014 | 1.381 | 0.979 | 11.66 |
| Erlotinib + HGF + Crizotinib | 0.023 | 0.417 | 0.085 | 1.095 |
• HGF activates pMET and pERK in the presence of Erlotinib.
• Crizotinib blocks HGF-induced pMET and pERK activation.
