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. 1973 Sep;70(9):2624–2628. doi: 10.1073/pnas.70.9.2624

Cell Interactions Between Histoincompatible T and B Lymphocytes. The H-2 Gene Complex Determines Successful Physiologic Lymphocyte Interactions*

David H Katz 1, Toshiyuki Hamaoka 1, Martin E Dorf 1, Baruj Benacerraf 1
PMCID: PMC427069  PMID: 4126264

Abstract

We used congenic-resistant mouse strains to answer questions concerning the respective roles of genes coding for major histocompatibility and background genotypes in T (thymus-derived)-B (bone marrow-derived) lymphocyte cooperative responses to hapten-protein conjugates. These studies demonstrate conclusively that the gene or genes present in the H-2 complex control the capacity of antigen-specific T and B cells to effectively interact. These findings led us to postulate that there exists on the B-lymphocyte surface an “acceptor” molecule for the active T-cell product or for the T cell itself.

Keywords: mice, hapten-protein conjugates

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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