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. 1973 Oct;70(10):2757–2761. doi: 10.1073/pnas.70.10.2757

Autoregulation: A Role for a Biosynthetic Enzyme in the Control of Gene Expression

David H Calhoun 1,*, G Wesley Hatfield 1
PMCID: PMC427103  PMID: 4583023

Abstract

It was previously proposed, primarily on the basis of evidence in vitro, that L-threonine deaminase, the ilvA gene product, is required for repression of its own synthesis and for repression of the other genes in the ilv-ADE operon. In this communication, evidence in vivo is presented that supports this autoregulatory model. Further evidence is presented that suggests that L-threonine deaminase is also required for induction of the ilvC gene product. The autoregulatory model is presented in an expanded form to include recent evidence that L-threonine deaminase (EC 4.2.1.16) is a central element for repression of the ilvADE and ilvB operons, and for induction of the ilvC operon.

Keywords: isoleucine-valine, multivalent repression, enzyme induction, L-threonine deaminase

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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