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. 1973 Oct;70(10):2832–2836. doi: 10.1073/pnas.70.10.2832

Strychnine Binding Associated with Glycine Receptors of the Central Nervous System

Anne B Young 1,2, Solomon H Snyder 1,2,*
PMCID: PMC427119  PMID: 4200724

Abstract

[3H]Strychnine binds to synaptic-membrane fractions of the spinal cord in a selective fashion, indicating an interaction with postsynaptic glycine receptors. Displacement of strychnine by glycine and other amino acids parallels their glycine-like neurophysiologic activity. The regional localization of strychnine binding in the central nervous system correlates closely with endogenous glycine concentrations. In subcellular fractionation experiments, strychnine binding is most enhanced in synaptic-membrane fractions. Strychnine binding is saturable, with affinity constants for glycine and strychnine of 10 and 0.03 μM, respectively.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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