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. 1973 Dec;70(12 Pt 1-2):3339–3343. doi: 10.1073/pnas.70.12.3339

The Presence of Ribonucleotides in Mature Closed-Circular Mitochondrial DNA

Lawrence I Grossman 1,2, Robert Watson 1,2, Jerome Vinograd 1,2
PMCID: PMC427232  PMID: 4202844

Abstract

Mitochondrial DNA from mouse and HeLa cells is nicked by alkali and chick-embryo ribonuclease H. It has been concluded that ribonucleotides are present in the closed-circular duplex. A comparative study of the scission rates at pH 13.0 of RNA and of mitochondrial DNAs indicates that there are no more than 10 ribonucleotides in the major fraction of the mitochondrial DNAs.

Keywords: ribonuclease H, alkali hydrolysis of DNA

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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