Table 1.
Compound 5-HT2 affinity and functional activitya.
| 5-HT2A | 5-HT2C | |
|---|---|---|
| Ro60-0175 | 32 nM agonist | 1 nM agonist |
|
|
||
| Ketanserin | 4 nM antagonist | 120 nM antagonist |
|
|
||
| (−)-trans-PAT | 80 nM inverse agonist | 20 nM agonist |
|
|
||
| (−)-trans-p-Cl-PAT | 240 nM inverse agonist | 130 nM agonist |
|
|
||
| m-Cl-6-OMe-PAT | 35 nM inverse agonist | 17 nM agonist |
|
|
||
| (−)-trans-CAT | 1.6 nM inverse agonist | 14 nM inverse agonist |
|
|
||
a
Booth et al., 2009; Choksi et al., 2000; Fiorella et al., 1995; Martin et al., 2004; Vincek and Booth, 2009.