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. Author manuscript; available in PMC: 2015 Oct 23.
Published in final edited form as: Oncogene. 2014 Jun 23;34(17):2204–2214. doi: 10.1038/onc.2014.168

Figure 7. miR-124 expression increases overall survival in an orthotopic intracranial mouse model.

Figure 7

(a) U87-MG cells transduced with either an empty control or pre-miR-124 expressing virus were injected into nude mice, subsequently surveyed for survival. Kaplan-Meier curve, *** p - value < 0.0001. (b) Representative H&E images of xenografts in the brain showing tumor lesions (arrows) at the time of sacrifice. (c) Model for miR-124 role in glioblastoma. miR-124 loss contributes to glioblastoma tumorigenesis by promoting the elevated expression of cell proliferation factors, as well as pro-survival factors, especially in regions experiencing nutrient and oxygen deprivation.