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. Author manuscript; available in PMC: 2015 Oct 30.
Published in final edited form as: Oncogene. 2014 Jun 23;34(18):2325–2336. doi: 10.1038/onc.2014.173

Figure 7. Model.

Figure 7

Ron stimulates Dek expression for sustained β-catenin signaling. Ron can directly activate intracellular β-catenin while Dek induces expression of Wnt ligands which are secreted into the tumor microenvironment to amplify β-catenin activity by autocrine and paracrine mechanisms.