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. 1972 Jan;69(1):134–138. doi: 10.1073/pnas.69.1.134

The Antibody Response of Mice to Murine Leukemia Virus in Spontaneous Infection: Absence of Classical Immunologic Tolerance

Michael B A Oldstone 1,2, Tadao Aoki 1,2,*, Frank J Dixon 1,2
PMCID: PMC427561  PMID: 4550501

Abstract

Gross murine leukemia virus is the etiologic agent of spontaneous leukemias of AKR mice. Despite the persistence of the Gross virus throughout their life, these mice are not immunologically tolerant to the virus. Specific antibodies to Gross antigens can be detected in the kidney where they have been deposited in the glomeruli, apparently in the form of Gross antigen-antibody complexes.

Keywords: AKR mice, complement-fixing antibodies, lymphocytic choriomeningitis virus, immunofluorescence, glomerular deposits of antigen-antibody complexes

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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