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. 1972 Jan;69(1):243–247. doi: 10.1073/pnas.69.1.243

Potassium: Effect on DNA Synthesis and Multiplication of Baby-Hamster Kidney Cells

C W Orr 1, M Yoshikawa-Fukada 1,*, J D Ebert 1,†
PMCID: PMC427584  PMID: 4333042

Abstract

The relations between DNA synthesis, cell multiplication, and external potassium concentration have been investigated in cultured baby-hamster kidney cells. When the potassium concentration was raised from 8 mM to 114 mM by equimolar replacement of sodium, DNA synthesis and cell multiplication were almost completely inhibited. This inhibition was reversible even after 72 hr of incubation in medium with a high concentration of potassium. There is a consistent difference between the cultured cells and polyoma virus-transformed cells in response to high-potassium medium, a higher-potassium concentration being required to inhibit multiplication of polyoma virus-transformed cells to the same extent as that of the nontransformed cells.

Keywords: cell cycle, membrane potential, synchronization, transformation

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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