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. 1995 Jan 17;92(2):480–482. doi: 10.1073/pnas.92.2.480

Genomic imprinting proposed as a surveillance mechanism for chromosome loss.

J H Thomas 1
PMCID: PMC42764  PMID: 7831314

Abstract

One consequence of genomic imprinting is that loss of the transcriptionally active chromosomal homologue causes a change in gene expression that might permit surveillance of chromosome-loss events. Possible selective advantages of such surveillance include protection against cancer and early elimination of monosomic and trisomic fetuses. Potential mechanisms for such surveillance are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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