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. 2014 Dec 11;6(12):4961–4998. doi: 10.3390/v6124961

Figure 1.

Figure 1

(a) Schematic representation of the linear KSHV genome with terminal repeat sequences, origin of lytic replication (ori-Lyt-A and ori-Lyt-B) and latency promoter; (b) The major latency locus of KSHV is shown in an expanded view. Top panel: The four major open reading frames (ORFs)-ORF73/LANA, ORF72/v-CYC, ORF 71/v-FLIP and ORF K12/Kaposins A-C along with the adjacent K14 and ORF74 genes are shown by green arrows. Position of 12 pre-miRNA sequences is shown as vertical red lines. Bottom panel: The schematic diagram of the transcripts directed by the Kaposin promoter (LTd) and the LANA promoter (LTc) is shown.