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. 2015 Jan 1;5(3):240–250. doi: 10.7150/thno.10226

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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C40-tPEG-Ex4-Cys (PEG-Ex4) promotes angiogenesis and preserves cardiac function via activating Akt and VEGF in a GLP-1 receptor dependent manner in vivo. A, Western blot analysis of VEGF in border zone of infarct myocardium. ^**P < 0.01 vs. vehicle; ^&&P < 0.01 vs. Ex4-P1. B, Capillary density measured by immunostaining for CD31 in the border region 7 days post injury. C, Arteriolar density measured by immunostaining for α-smooth muscle actin in the border region 14 days after infarction. ^*P < 0.05 vs. MI, ^**P < 0.01 vs. MI; ^&P < 0.05 vs. Ex4-P1, ^&&P < 0.01 vs. Ex4-P1.