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. 2014 Oct 24;5(21):10778–10790. doi: 10.18632/oncotarget.2502

Figure 1. CBX8 was up-regulated and essential for growth in human colorectal cancer.

Figure 1

(A) The CBX8 protein levels in eight pairs of CRC tumor tissues (T) and their non-tumor counterparts (N) were detected by western blotting. (B, C) IHC for CBX8 was performed using 164 clinical CRC samples as described in the Materials and Methods section. Subpanel B shows 4 representative images, and subpanel C illustrates the statistical results of a Mann-Whitney test (*p < 0.05). The dots represent the scores, and the bars indicate the SD. (D) In the indicated cell lines, proteins were analyzed (left panel), and cell viability was measured by MTT (middle and right panels). The dots represent the means, and the bars indicate the SD. *p < 0.05 using the independent Student t test (n=3). (E, F) The in vivo growth of the indicated stable cell lines was examined as described in the Materials and Methods. The images and weight of xenograft tumors are shown in the left and right sides of E and F, respectively. The dots represent the weights, and the bars indicate the SD. *p < 0.05 using the independent Student t test (n=6).